Archaeal DNA - alkyltransferase 1 Activity and Regulation of an Archaeal DNA - Alkyltransferase : a Conserved Protein Involved
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چکیده
Background: DNA-alkyltransferases repair mutagenic and carcinogenic alkylation DNA lesions. Results: A thermophilic archaeal DNAalkyltransferase is degraded after alkylation in vivo. A novel assay is applied to study its activity in vitro. Conclusion: The archaeal DNA-alkyltransferase shows structure, activity and in vivo regulation similar to its human homolog. Significance: The function and regulation of DNA-alkyltransferases might be conserved from archaea to humans.
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تاریخ انتشار 2011